Growth and Replication of Living Organisms


Growth and Replication of Living Organisms. General Law of Growth and Replication and the Unity of Biochemical and Physical Mechanisms

by Yuri K. Shestopaloff

ISBN 978-0-9877785-0-5 (First Edition)

ISBN 978-0-9877785-7-4 (Second Revised Edition)

Library of Congress Control Number:  2011916768

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Editorial Review

The book “Growth and replication of living organisms. General law of growth and replication and the unity of biochemical and physical mechanisms” by Yuri Shestopaloff significantly enhances previously published results of his studies of growth mechanisms. In fact, the depth and comprehensiveness of this research allowed the author to introduce and prove the existence of a general growth law, which unites the physical and biochemical growth factors, and is universally applicable to growth, replication, existence, and development of all living organisms.

     Of course, it is hard to believe that once you read the book, you will know why and how the miracle of life appeared and exists. And nonetheless, this is what this book is about. Recall the discovery of laws of mechanics by Newton. Did anybody pay attention when Newton discovered the general laws of mechanics and gravitation? Not really. The general growth law is of no less importance for life scientists, as laws of mechanics are for physicists. Knowledge of this general growth law gives an edge in all biology related studies, since this growth law universally governs the growth of all living organisms and is influentially present in any biological phenomena. The author presents many convincing examples of practical applications of the discovered law in biotechnology, cell biology, development biology, etc. Beginning as a particular mathematical model of the cell growth, the research went through several qualitative phases, before the originally introduced physical growth mechanism became a credible theory about the general growth law that universally governs the growth and replication of all living species, from organelles to humans. Reviews of the author's previous book on physics of growth and replication and first edition of this book are very positive.



This densely packed book has 246 pages, about 73,300 words, includes 52 graphical illustrations, 8 tables, extensive bibliography and index table. The author considers the growth as a single process both from the physical and biochemical perspectives. These two types of growth mechanisms form a single mechanism that governs the growth of all living organisms and their constituents. The presented findings relate and connect numerous aspects and specific features of growth and replication, which previously were considered as unrelated fragments, into a single growth and replication phenomenon governed by a general law of Nature.

    This book continues studies of growth mechanisms by the same author. Results of earlier research have been published in books and scientific journals. Growth is considered as a phenomenon governed by the unity of physical and biochemical growth mechanisms. The findings relate and connect numerous aspects of growth and replication, which previously were considered to be unrelated fragments, into a single phenomenon governed by a general law of Nature, introduced in this book. It was discovered that the answer to the growth puzzle resides both in the physical and biochemical realms. Geometrical characteristics of an organism uniquely define the distribution of nutritional resources between maintenance needs and biomass synthesis, through the growth ratio parameter, which monotonically decreases during growth. In turn, the fraction of nutritional resources diverted towards biomass synthesis defines the amount of synthesized biomass, and through this, the composition of biochemical reactions. Thus, during growth, combined changes in an organism’s geometry and related changes of distribution of influx of nutrients influence the composition of biochemical reactions in such a way that organisms progress through the whole growth cycle. In addition, the book considers growth of populations, based on two discovered typical growth scenarios of individual organisms, and introduces new general formulas for population growth. The material is well presented. Any person interested in the subject and familiar with the basics of physics and biology will understand the introduced concepts and the whole content, which is much facilitated by numerous graphical illustrations and numerical examples.

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Last modified: 04/25/15